Influence of fetal blood flow redistribution on fetal and childhood growth and fat distribution: the Generation R Study.

ABSTRACT:

Objective

A suboptimal intrauterine environment leads to fetal blood flow redistribution and fetal growth restriction. Not much is known about childhood growth consequences. We examined the associations of fetal blood flow redistribution with birth outcomes, and repeatedly measured fetal and childhood growth and fat mass measures.

Design

Prospective cohort study.

Setting

Population-based.

Population

One thousand one hundred and ninety-five pregnant women and their children.

Methods

We measured umbilical and cerebral artery blood flow at a gestational age of 30.3 weeks (95% range, 28.5-32.6 weeks). A higher umbilical/cerebral (U/C) pulsatility index ratio is an indicator of preferential blood flow to the brain cerebral circulation at the expense of the lo

SUBMITTER: Kooijman MN 

PROVIDER: S-EPMC5427172 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature