Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants.

ABSTRACT:

Aims

The purpose of this study was to explore clinical markers reflecting developmental changes in drug clearance by preterm infants.

Methods

Preterm infants administered aminophylline or theophylline to treat apnoea of prematurity were enrolled in this study. Trough and one of 2 h, 4 h or 6 h post-dose blood samples and urine samples were collected during steady state, to determine the concentrations of theophylline and its targeted metabolites. CYP1A2*1C and CYP1A2*1F genotypes were analyzed. Total, renal and nonrenal clearances of theophylline were calculated, and cytochrome P450 1A2 (CYP1A2) activity was obtained from the ratio of 1-methyluric acid and 3-methylxanthine to theophylline in urine. Multiple linear regression analysis was performed to evaluate the relationshi

SUBMITTER: Sohn JA 

PROVIDER: S-EPMC5427230 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature