Ontology highlight
ABSTRACT:
SUBMITTER: Xu L
PROVIDER: S-EPMC5427473 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
EXCLI journal 20170307
Differential expression of microRNAs (miRNAs) has been implicated in leukemogenesis. We investigate the expression pattern of miR-196b. Using quantitative real-time PCR (qRT-PCR), we detected the expression of miR-196b and its correlated genes (SMC1A/MLH1) in initial pediatric AML. A significant association was observed between overexpression of miR-196b and inferior overall survival of pediatric AML (Log Rank <i>P</i><0.0001). AML M4/5 subtype, high white blood cell (WBC) count at presentation, ...[more]