Impact of the FSHB gene -211G/T polymorphism on male gonadal function.

ABSTRACT:

Purpose

The FSHB gene -211G/T polymorphism has been reported to modulate gene expression and to cause inter-individual differences in FSH serum levels in men. This study was undertaken to assess the functional relevance of this polymorphism on gonadotropin and total testosterone serum levels and sperm parameters in men from Eastern Sicily (Italy).

Methods

To accomplish this, 200 men with abnormal conventional sperm parameters or normozoospermia (according to the parameters of WHO 2010) were genotyped by TaqMan Assay.

Results

The frequency of FSHB -211 T allele was significantly higher (p < 0.005) in patients with altered conventional sperm parameters (18.9% of chromosomes) compared to that observed in men with normozoospermia (10.9% of chromosomes). Decreasing serum l

SUBMITTER: Tamburino L 

PROVIDER: S-EPMC5427649 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature