In vitro fertilization for women infected by hepatitis C virus: a matched case-control study and a systematic literature review.

ABSTRACT:

Purpose

The aim of this study was to investigate whether infection of women by the hepatitis C virus (HCV) reduces the chance of conceiving after in vitro fertilization (IVF).

Methods

We performed a retrospective blind matched case-control study where IVF outcomes for the first 37 cycles of HCV sero-positive women were compared to those of 107 cycles of an uninfected control group. Our results were included in a systematic literature review.

Results

Out of five eligible studies, ours included, three observed an impact of HCV infection, though at various levels including response to stimulation, fertilization, implantation, and pregnancy rates. Two studies differentiated results for patients with confirmed active viral replication. Matching criteria and populations stu

SUBMITTER: Shaw-Jackson C 

PROVIDER: S-EPMC5427650 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature