House Dust Endotoxin Levels Are Associated with Adult Asthma in a U.S. Farming Population.

ABSTRACT:

Rationale

Endotoxin initiates a proinflammatory response from the innate immune system. Studies in children suggest that endotoxin exposure from house dust may be an important risk factor for asthma, but few studies have been conducted in adult populations.

Objectives

To investigate the association of house dust endotoxin levels with asthma and related phenotypes (wheeze, atopy, and pulmonary function) in a large U.S. farming population.

Methods

Dust was collected from the bedrooms (n = 2,485) of participants enrolled in a case-control study of current asthma (927 cases) nested within the Agricultural Health Study. Dust endotoxin was measured by Limulus amebocyte lysate assay. Outcomes were measured by questionnaire, spirometry, and blood draw. We evaluated associatio

SUBMITTER: Carnes MU 

PROVIDER: S-EPMC5427722 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature