KCC2 downregulation facilitates epileptic seizures.

ABSTRACT: GABA_A receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl^-] concentration, which in adult depends on neuron specific K⁺-Cl^- cotransporter-2 (KCC2). Previous studies have shown that KCC2 was downregulated in both epileptic patients and various epileptic animal models. However, the temporal relationship between KCC2 downregulation and seizure induction is unclear yet. In this study, we explored the temporal relationship and the influence of KCC2 downregulation on seizure induction. Significant downregulation of plasma membrane KCC2 was directly associated with severe (Racine Score III and above) behavioral seizures in vivo, and occurred before epileptiform bursting activities in vitro induced by convulsant. Overex

SUBMITTER: Chen L 

PROVIDER: S-EPMC5427808 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature