Ontology highlight
ABSTRACT:
SUBMITTER: Doiron K
PROVIDER: S-EPMC5427825 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Doiron Karine K Goyon Vanessa V Coyaud Etienne E Rajapakse Sanjeeva S Raught Brian B McBride Heidi M HM
Scientific reports 20170307 1
Activation of the innate immune response triggered by dsRNA viruses occurs through the assembly of the Mitochondrial Anti-Viral Signaling (MAVS) complex. Upon recognition of viral dsRNA, the cytosolic receptor RIG-I is activated and recruited to MAVS to activate the immune signaling response. We here demonstrate a strict requirement for a mitochondrial anchored protein ligase, MAPL (also called MUL1) in the signaling events that drive the transcriptional activation of antiviral genes downstream ...[more]