Different definitions of esophagus influence esophageal toxicity prediction for esophageal cancer patients administered simultaneous integrated boost versus standard-dose radiation therapy.

ABSTRACT: We aim to evaluate whether different definitions of esophagus (DEs) impact on the esophageal toxicity prediction for esophageal cancer (EC) patients administered intensity-modulated radiation therapy with simultaneous integrated boost (SIB-IMRT) vs. standard-dose IMRT (SD-IMRT). The esophagus for 21 patients diagnosed with primary EC were defined in the following four ways: the whole esophagus, including the tumor (ESO_whole); ESO_whole within the treatment field (ESO_infield); ESO_infield, excluding the tumor (ESO_{infield-tumor}) and ESO_whole, excluding the tumor (ESO_whole-tumor). The difference in the dose variation, acute esophageal toxicity (AET) and late esophageal toxicity (LET) of four DEs were compared. We found

SUBMITTER: Huang BT 

PROVIDER: S-EPMC5427902 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature