Cutaneous squamous cell cancer (cSCC) risk and the human leukocyte antigen (HLA) system.

ABSTRACT: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer among Caucasians in the United States, with rising incidence over the past decade. Treatment for non-melanoma skin cancer, including cSCC, in the United States was estimated to cost $4.8 billion in 2014. Thus, an understanding of cSCC pathogenesis could have important public health implications. Immune function impacts cSCC risk, given that cSCC incidence rates are substantially higher in patients with compromised immune systems. We report a systematic review of published associations between cSCC risk and the human leukocyte antigen (HLA) system. This review includes studies that analyze germline class I and class II HLA allelic variation as well as HLA cell-surface protein expression levels associated with cSCC ris

SUBMITTER: Yesantharao P 

PROVIDER: S-EPMC5428079 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature