Prognostic value of CA20, a score based on centrosome amplification-associated genes, in breast tumors.

ABSTRACT: Centrosome amplification (CA) is a hallmark of cancer, observable in ≥75% of breast tumors. CA drives aggressive cellular phenotypes such as chromosomal instability (CIN) and invasiveness. Thus, assessment of CA may offer insights into the prognosis of breast cancer and identify patients who might benefit from centrosome declustering agents. However, it remains unclear whether CA is correlated with clinical outcomes after adjusting for confounding factors. To gain insights, we developed a signature, "CA20", comprising centrosome structural genes and genes whose dysregulation is implicated in inducing CA. We found that CA20 was a significant independent predictor of worse survival in two large independent datasets after adjusting for potentially confounding factors. In multivariable analyse

SUBMITTER: Ogden A 

PROVIDER: S-EPMC5428291 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature