Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.

ABSTRACT: The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride concentrations regulated by Na⁺-K⁺-2Cl^- cotransporter 1 (NKCC1) and neuronal K⁺-Cl^- cotransporter 2 (KCC2), allowing entrance and efflux of chloride, respectively. Modifications in NKCC1 and KCC2 expression during maturation of cortical cells induce a shift in GABAergic signaling. Here, we demonstrated that APP affects this GABA shift. Expression of APP in cortical cells decreased the expression of KCC2, without modifying NKCC1, eliciting a less inhibitory GABA response. Downregulation of KCC2 expressi

SUBMITTER: Doshina A 

PROVIDER: S-EPMC5428293 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature