Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence.

ABSTRACT: The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging. However, this hypothesis remains to be fully tested. Here, we studied 6 young and 12 old Chinese rhesus macaques (ChRM) over the course of three months after simian immunodeficiency virus (SIV) SIVmac239 infection. Old ChRM showed a higher risk of accelerated AIDS development than did young macaques, owing to rapidly elevated plasma viral loads and decreased levels of CD4⁺ T cells. The low frequency of naïve CD4⁺ T cells before infection was strongly predictive of an increased disease progression, whereas the severe depletion of CD4⁺ T cells and the rapid

SUBMITTER: Zheng HY 

PROVIDER: S-EPMC5428349 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature