Context-independent essential regulatory interactions for apoptosis and hypertrophy in the cardiac signaling network.

ABSTRACT: Apoptosis and hypertrophy of cardiomyocytes are the primary causes of heart failure and are known to be regulated by complex interactions in the underlying intracellular signaling network. Previous experimental studies were successful in identifying some key signaling components, but most of the findings were confined to particular experimental conditions corresponding to specific cellular contexts. A question then arises as to whether there might be essential regulatory interactions that prevail across diverse cellular contexts. To address this question, we have constructed a large-scale cardiac signaling network by integrating previous experimental results and developed a mathematical model using normalized ordinary differential equations. Specific cellular contexts were reflected to dif

SUBMITTER: Kang JH 

PROVIDER: S-EPMC5428364 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature