MiR-503 Promotes Bone Formation in Distraction Osteogenesis through Suppressing Smurf1 Expression.

ABSTRACT: Distraction osteogenesis (DO) is a unique technique for promoting bone formation in clinical practice. However the underlying mechanism remains elusive. As epigenetic mediators, microRNAs have been reported to play important roles in regulating osteogenesis. In this study, after successfully established the DO model of rats, a microRNA microarray was performed to find molecular targets for DO. Total 100 microRNAs were identified as differently expressed, with miR-503 being one of the most significantly up-regulated miRNAs in DO. The further investigation also showed that miR-503 was upregulated during osteogenesis in mesenchymal stem cells of rats, and overexpression of miR-503 significantly promoted osteogenesis in vitro and accelerated mineralization in DO process in vivo. By using bioin

SUBMITTER: Sun Y 

PROVIDER: S-EPMC5428455 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature