X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice.

ABSTRACT: Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Within this letter, we propose to exploit X-ray dark-field imaging as a novel diagnostic tool for the detection of lung cancer on projection radiographs. Here, we demonstrate in living mice bearing lung tumors, that X-ray dark-field radiography provides significantly improved lung tumor detection rates without increasing the number of false-positives, especially in the case of small and superimposed nodules, when compared to conventional absorption-based imaging. While this meth

SUBMITTER: Scherer K 

PROVIDER: S-EPMC5428469 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature