Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury.

ABSTRACT: Successful tissue repair requires the activities of myeloid cells such as monocytes and macrophages that guide the progression of inflammation and healing outcome. Immunoregenerative materials leverage the function of endogenous immune cells to orchestrate complex mechanisms of repair; however, a deeper understanding of innate immune cell function in inflamed tissues and their subsequent interactions with implanted materials is necessary to guide the design of these materials. Blood monocytes exist in two primary subpopulations, characterized as classical inflammatory or non-classical. While classical monocytes extravasate into inflamed tissue and give rise to macrophages or dendritic cells, the recruitment kinetics and functional role of non-classical monocytes remains unclear. Here, we d

SUBMITTER: Olingy CE 

PROVIDER: S-EPMC5428475 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature