Prognostic and clinicopathological significance of cyclin B expression in patients with breast cancer: A meta-analysis.

ABSTRACT:

Background

Cyclin B plays a crucial role in cancer cell cycle progression and is overexpressed in many human cancers, including breast cancer. However, the prognostic value of cyclin B expression in breast cancer is controversial. We performed a meta-analysis to assess the clinicopathological and prognostic significance of cyclin B expression in breast cancer.

Methods

We searched PubMed, web of science, and Embase databases to retrieve the publications investigating the association between cyclin B expression and clinicopathological/prognostic significance in breast cancer patients. The pooled hazard ratio (HR) or odds ratio (OR) with its 95% confidence intervals (CIs) were used to estimate the effects.

Results

Ten studies with 2366 breast cancer patients were include

SUBMITTER: Sun X 

PROVIDER: S-EPMC5428614 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature