Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.

ABSTRACT: Chronic renal failure (CRF) is a major public health problem worldwide. Hydrogen sulfide (H₂S) plays important roles in renal physiological and pathophysiological processes. However, whether H₂S could protect against CRF in rats remains unclear. In this study, we found that H₂S alleviated gentamicin-induced nephrotoxicity by reducing reactive oxygen species (ROS)-mediated apoptosis in normal rat kidney-52E cells. We demonstrated that H₂S significantly improved the kidney structure and function of CRF rats. We found that H₂S decreased the protein levels of Bax, Caspase-3, and Cleaved-caspase-3, but increased the expression of Bcl-2. Treatment with H₂S reduced the levels of malondialdehyde and ROS and increased the activities

SUBMITTER: Wu D 

PROVIDER: S-EPMC5428696 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature