Neopeptide Analyser: A software tool for neopeptide discovery in proteomics data.

ABSTRACT: Experiments involving mass spectrometry (MS)-based proteomics are widely used for analyses of connective tissues. Common examples include the use of relative quantification to identify differentially expressed peptides and proteins in cartilage and tendon. We are working on characterising so-called 'neopeptides', i.e. peptides formed due to native cleavage of proteins, for example under pathological conditions. Unlike peptides typically quantified in MS workflows due to the in vitro use of an enzyme such as trypsin, a neopeptide has at least one terminus that was not due to the use of trypsin in the workflow. The identification of neopeptides within these datasets is important in understanding disease pathology, and the development of antibodies that could be utilised as diagnostic

SUBMITTER: Peffers M 

PROVIDER: S-EPMC5428739 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature