Cytomegalovirus infection exacerbates autoimmune mediated neuroinflammation.

ABSTRACT: Cytomegalovirus (CMV) is a latent virus which causes chronic activation of the immune system. Here, we demonstrate that cytotoxic and pro-inflammatory CD4⁺CD28^null T cells are only present in CMV seropositive donors and that CMV-specific Immunoglobulin (Ig) G titers correlate with the percentage of these cells. In vitro stimulation of peripheral blood mononuclear cells with CMVpp65 peptide resulted in the expansion of pre-existing CD4⁺CD28^null T cells. In vivo, we observed de novo formation, as well as expansion of CD4⁺CD28^null T cells in two different chronic inflammation models, namely the murine CMV (MCMV) model and the experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis (MS). In EAE, the percenta

SUBMITTER: Vanheusden M 

PROVIDER: S-EPMC5428769 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature