TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents.

ABSTRACT: Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably contribute to its pathophysiology. For example, thymic stromal lymphopoietin (TSLP) is highly expressed in lesional atopic skin and significantly contributes to the pathogenesis of AD by activating dendritic cells that then initiate downstream effects on, for example, T cells. However, little is known about the direct interplay between TSLP, filaggrin-deficient skin and other immune cells such as T lymphocytes. In the present study, FLG knockdown skin equivalents, characterised by intrinsically high TSLP levels, were exposed to activated CD4⁺ T cells. T cell exposure resulted in an inflammatory phe

SUBMITTER: Wallmeyer L 

PROVIDER: S-EPMC5428778 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature