The role of Lon-mediated proteolysis in the dynamics of mitochondrial nucleic acid-protein complexes.

ABSTRACT: Mitochondrial nucleoids consist of several different groups of proteins, many of which are involved in essential cellular processes such as the replication, repair and transcription of the mitochondrial genome. The eukaryotic, ATP-dependent protease Lon is found within the central nucleoid region, though little is presently known about its role there. Aside from its association with mitochondrial nucleoids, human Lon also specifically interacts with RNA. Recently, Lon was shown to regulate TFAM, the most abundant mtDNA structural factor in human mitochondria. To determine whether Lon also regulates other mitochondrial nucleoid- or ribosome-associated proteins, we examined the in vitro digestion profiles of the Saccharomyces cerevisiae TFAM functional homologue Abf2, the yeast mtDNA mainten

SUBMITTER: Kunova N 

PROVIDER: S-EPMC5428876 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature