Associations of androgens with depressive symptoms and cognitive status in the general population.

ABSTRACT:

Objectives

Associations between androgens and depressive symptoms were mostly reported from cross-sectional and patient-based studies.

Study design/main outcome measures

Longitudinal data from 4,110 participants of the Study of Health in Pomerania were used to assess sex-specific associations of baseline total and free testosterone, androstenedione and sex hormone-binding globulin with incident depressive symptoms and cognitive status at 5- and 10-year follow-up.

Results

Despite sex-specific differences in depressive symptoms prevalence at baseline (women: 17.4%, men: 8.1%), cross-sectional analyses showed no associations between sex hormones and depressive symptoms. In age-adjusted longitudinal analyses, total testosterone was associated with incident depressive symp

SUBMITTER: Kische H 

PROVIDER: S-EPMC5428943 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature