Flashing Lights Induce Prolonged Distortions in Visual Cortical Responses and Visual Perception.

ABSTRACT: The primary sensory neocortex generates an internal representation of the environment, and its circuit reorganization is thought to lead to a modification of sensory perception. This reorganization occurs primarily through activity-dependent plasticity and has been well documented in animals during early developmental stages. Here, we describe a new method for the noninvasive induction of long-term plasticity in the mature brain: simple transient visual stimuli (i.e., flashing lights) can be used to induce prolonged modifications in visual cortical processing and visually driven behaviors. Our previous studies have shown that, in the primary visual cortex (V1) of mice, a flashing light stimulus evokes a long-delayed response that persists for seconds. When the mice were repetitively presen

SUBMITTER: Minamisawa G 

PROVIDER: S-EPMC5429040 | biostudies-literature | 2017 May-Jun

REPOSITORIES: biostudies-literature