Prospective study of oral anticoagulants and risk of liver injury in patients with atrial fibrillation.

ABSTRACT:

Objective

To assess the risk of liver injury hospitalisation in patients with atrial fibrillation (AF) after initiation of direct oral anticoagulants (DOACs) or warfarin and to determine predictors of liver injury hospitalisation in this population.

Methods

We studied 113 717 patients (mean age 70, 39% women) with AF included in the MarketScan Commercial and Medicare Supplemental databases with a first prescription for oral anticoagulation after 4 November 2011, followed through 31 December 2014. Of these, 56 879 initiated warfarin, 17 286 initiated dabigatran, 30 347 initiated rivaroxaban and 9205 initiated apixaban. Liver injury hospitalisation and comorbidities were identified from healthcare claims.

Results

During a median follow-up of 12 months, 960 hospitalisati

SUBMITTER: Alonso A 

PROVIDER: S-EPMC5429195 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature