A case-control study of selenoprotein genes polymorphisms and autoimmune thyroid diseases in a Chinese population.

ABSTRACT:

Background

Selenium is an essential trace and there is a high selenium concentration in the thyroid gland. Selenium deficiency may impair the thyroid function. The aim of this study was to investigate the association between three selenoprotein genes polymorphisms and autoimmune thyroid diseases.

Methods

We genotyped six single-nucleotide polymorphisms (SNPs), rs6865453 in selenoprotein P gene (SELENOP), rs713041 rs2074451 rs3746165 in glutathione peroxidase 4 gene (GPX4) and rs28665122 and rs7178239 in selenoprotein S gene (SELENOS) by MassARRAY system using the chip-based matrix-assisted laser desorption ionization time-of-flight mass spectrometry technology in 1060 patients with autoimmune thyroid diseases and 938 healthy controls.

Results

Major alleles in rs686545

SUBMITTER: Xiao L 

PROVIDER: S-EPMC5429515 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature