Novel glycolipid agents for killing cisplatin-resistant human epithelial ovarian cancer cells.

ABSTRACT:

Background

Chemotherapy resistance is one of the major factors contributing to mortality from human epithelial ovarian cancer (EOC). Identifying drugs that can effectively kill chemotherapy-resistant EOC cells would be a major advance in reducing mortality. Glycosylated antitumour ether lipids (GAELs) are synthetic glycolipids that are cytotoxic to a wide range of cancer cells. They appear to induce cancer cell death in an apoptosis-independent manner.

Methods

Herein, the effectiveness of two GAELs, GLN and MO-101, in killing chemotherapy-sensitive and -resistant EOC cells lines and primary cell samples was tested using monolayer, non-adherent aggregate, and non-adherent spheroid cultures.

Results

Our results show that EOC cells exhibit a differential sensitivity to t

SUBMITTER: Moraya AI 

PROVIDER: S-EPMC5429581 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature