Statins and Exercise Training Response in Heart Failure Patients: Insights From HF-ACTION.

ABSTRACT:

Objectives

The aim of this study was to assess for a treatment interaction between statin use and exercise training (ET) response.

Background

Recent data suggest that statins may attenuate ET response, but limited data exist in patients with heart failure (HF).

Methods

HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) was a randomized trial of 2,331 patients with chronic HF with ejection fraction ≤35% who were randomized to usual care with or without ET. We evaluated whether there was a treatment interaction between statins and ET response for the change in quality of life and aerobic capacity (peak oxygen consumption and 6-min walk distance) from baseline to 3 months. We also assessed for a treatment interaction among atorvasta

SUBMITTER: Kelly JP 

PROVIDER: S-EPMC5429584 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature