RPI-Bind: a structure-based method for accurate identification of RNA-protein binding sites.

ABSTRACT: RNA and protein interactions play crucial roles in multiple biological processes, while these interactions are significantly influenced by the structures and sequences of protein and RNA molecules. In this study, we first performed an analysis of RNA-protein interacting complexes, and identified interface properties of sequences and structures, which reveal the diverse nature of the binding sites. With the observations, we built a three-step prediction model, namely RPI-Bind, for the identification of RNA-protein binding regions using the sequences and structures of both proteins and RNAs. The three steps include 1) the prediction of RNA binding regions on protein, 2) the prediction of protein binding regions on RNA, and 3) the prediction of interacting regions on both RNA and protein simu

SUBMITTER: Luo J 

PROVIDER: S-EPMC5429624 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature