Cancer-associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression.

ABSTRACT: Cancer is a multifactorial disease driven by a combination of genetic and environmental factors. Many cancer driver mutations have been characterised in protein-coding regions of the genome. However, mutations in noncoding regions associated with cancer have been less investigated. G-quadruplex (G4) nucleic acids are four-stranded secondary structures formed in guanine-rich sequences and prevalent in the regulatory regions. In this study, we used published whole cancer genome sequence data to find mutations in cancer patients that overlap potential RNA G4-forming sequences in 5' UTRs. Using RNAfold, we assessed the effect of these mutations on the thermodynamic stability of predicted RNA G4s in the context of full-length 5' UTRs. Of the 217 identified mutations, we found that 33 are predic

SUBMITTER: Zeraati M 

PROVIDER: S-EPMC5429658 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature