P2Y₆-deficiency increases micturition frequency and attenuates sustained contractility of the urinary bladder in mice.

ABSTRACT: The role of the P2Y₆ receptor in bladder function has recently attracted a great deal of attention in lower urinary tract research. We conducted this study to determine contributions of the P2Y₆ receptor in lower urinary tract function of normal phenotypes by comparing P2Y₆-deficient mice and wild-type mice. In in vivo experiments, P2Y₆-deficient mice had more frequent micturition with smaller bladder capacity compared to wild-type mice; however, there was no difference between these groups in bladder-filling pressure/volume relationships during cystometry under decerebrate, unanaesthetized conditions. Analysis of in vivo bladder contraction revealed significant difference between the 2 groups, with P2Y₆-deficient mice presenting marke

SUBMITTER: Kira S 

PROVIDER: S-EPMC5429706 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature