Moderate plasma dilution using artificial plasma expanders shifts the haemostatic balance to hypercoagulation.

ABSTRACT: Artificial plasma expanders (PEs) are widely used in modern transfusion medicine. PEs do not contain components of the coagulation system, so their infusion in large volumes causes haemodilution and affects haemostasis. However, the existing information on this effect is contradictory. We studied the effect of the very process of plasma dilution on coagulation and tested the hypothesis that moderate dilution with a PE should accelerate clotting owing to a decrease in concentration of coagulation inhibitors. The standard clotting times, a thrombin generation test, and the spatial rate of clot growth (test of thrombodynamics) were used to assess donor plasma diluted in vitro with various PEs. The pH value and Ca⁺² concentration were maintained strictly constant in all samples. The

SUBMITTER: Sinauridze EI 

PROVIDER: S-EPMC5429808 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature