Global gene expression profiling of healthy human brain and its application in studying neurological disorders.

ABSTRACT: Brain function is governed by precise regulation of gene expression across its anatomically distinct structures; however, the expression patterns of genes across hundreds of brain structures are not clearly understood. Here, we describe a gene expression model, which is representative of the healthy human brain transcriptome by using data from the Allen Brain Atlas. Our in-depth gene expression profiling revealed that 84% of genes are expressed in at least one of the 190 brain structures studied. Hierarchical clustering based on gene expression profiles delineated brain regions into structurally tiered spatial groups and we observed striking enrichment for region-specific processes. Further, weighted co-expression network analysis identified 19 robust modules of highly correlated genes enr

SUBMITTER: Negi SK 

PROVIDER: S-EPMC5429860 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature