Network evolution in mesial temporal lobe epilepsy revealed by diffusion tensor imaging.

ABSTRACT:

Objective

The objective of the present study is to identify novel, time-indexed imaging biomarkers of epileptogenesis in mesial temporal lobe epilepsy (MTLE).

Methods

We used high-resolution brain diffusion tensor imaging (DTI) of the translationally relevant methionine sulfoximine (MSO) brain infusion model of MTLE. MSO inhibits astroglial glutamine synthetase, which is deficient in the epileptogenic hippocampal formation of patients with MTLE. MSO-infused (epileptogenic) rats were compared with phosphate-buffered saline (PBS)-infused (nonepileptogenic) rats at early (3-4 days) and late (6-9 weeks) time points during epileptogenesis.

Results

The epileptogenic rats exhibited significant changes in DTI-measured fractional anisotropy (FA) in numerous brain regions versu

SUBMITTER: Wang H 

PROVIDER: S-EPMC5429866 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature