Association between neuroendocrine tumors biomarkers and primary tumor site and disease type based on total ⁶⁸Ga-DOTATATE-Avid tumor volume measurements.

ABSTRACT:

Objective

To determine the association between neuroendocrine tumor (NET) biomarker levels and the extent of disease as assessed by ⁶⁸Ga DOTATATE PET/CT imaging.

Design

A retrospective analysis of a prospective database of patients with NETs.

Methods

Fasting plasma chromogranin A (CgA), neuron-specific enolase (NSE), gastrin, glucagon, vasoactive intestinal peptide (VIP) and pancreatic polypeptide (PP), and 24-h urinary 5-hydroxyindoleacetic acid (5-HIAA) levels were measured. Correlation between biomarkers and total ⁶⁸Ga-DOTATATE-avid tumor volume (TV) was analyzed.

Results

The analysis included 232 patients. In patients with pancreatic NETs (n = 112), ⁶⁸Ga-DOTATATE TV correlated with CgA (r = 0.6, P = 0.00

SUBMITTER: Tirosh A 

PROVIDER: S-EPMC5430160 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature