Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery.

ABSTRACT:

Background

Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components that accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ injury in transfused patients.

Methods

Cardiac surgery patients at increased risk of large-volume RBC transfusion were eligible. Participants were randomized to receive either mechanically washed allogenic RBCs or standard care RBCs. The primary outcome was serum interleukin-8 measured at baseline and at four postsurgery time points. A mechanism substudy evaluated the effects of washing on stored RBCs in vitro and on markers of platelet, leucocyte, and endothelial activation in trial subjects.

Results

Sixty adult cardiac surgery patients at three UK cardi

SUBMITTER: Wozniak MJ 

PROVIDER: S-EPMC5430295 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature