Folium Sennae protects against hydroxyl radical-induced DNA damage via antioxidant mechanism: an in vitro study.

ABSTRACT:

Background

In the study, Folium Sennae (FS) was firstly extracted by various solvents to obtain five FS extracts. Then, five FS extracts were evaluated for the protective effects against •OH-induced DNA damage, antioxidant abilities in vitro, and chemical contents using various methods. On this basis, the correlation graphs between the pharmacological effects and chemical contents were plotted to obtain the correlation coefficients (R values). Finally, in order to obtain biological evidence, ethyl acetate extract of FS (EAFS) was investigated for the protective effect against •OH-induced MSCs (mesenchymal stem cells) damage using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl) assay.

Results

The pharmacological assays indicated that five FS extracts could effectively protect

SUBMITTER: Lin J 

PROVIDER: S-EPMC5430338 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature