[¹⁸F]tetrafluoroborate-PET/CT enables sensitive tumor and metastasis in vivo imaging in a sodium iodide symporter-expressing tumor model.

ABSTRACT: Cancer cell metastasis is responsible for most cancer deaths. Non-invasive in vivo cancer cell tracking in spontaneously metastasizing tumor models still poses a challenge requiring highest sensitivity and excellent contrast. The goal of this study was to evaluate if the recently introduced PET radiotracer [¹⁸F]tetrafluoroborate ([¹⁸F]BF₄^-) is useful for sensitive and specific metastasis detection in an orthotopic xenograft breast cancer model expressing the human sodium iodide symporter (NIS) as a reporter. In vivo imaging was complemented by ex vivo fluorescence microscopy and γ-counting of harvested tissues. Radionuclide imaging with [¹⁸F]BF₄^- (PET/CT) was compared to the conventional tracer [¹²³I]io

SUBMITTER: Diocou S 

PROVIDER: S-EPMC5430436 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature