Ontology highlight
ABSTRACT:
SUBMITTER: Mahadevappa R
PROVIDER: S-EPMC5430515 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Mahadevappa Ravikiran R Neves Henrique H Yuen Shun Ming SM Bai Yuchen Y McCrudden Cian M CM Yuen Hiu Fung HF Wen Qing Q Zhang Shu Dong SD Kwok Hang Fai HF
Scientific reports 20170420 1
DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers are largely unknown. In the present study, we have shown that the expression levels of Cdc6 and Cdt1 were both significantly correlated with an increasing number of MCM2-7 genes overexpression. Both Cdc6 and Cdt1, when expressed in a high level, al ...[more]