Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions.

ABSTRACT: Despite its population, geographic size, and emerging economic importance, disproportionately little genome-scale research exists into genetic factors that predispose Brazilians to disease, or the population genetics of risk. After identification of suitable proxy populations and careful analysis of tri-continental admixture in 1,538 North-Eastern Brazilians to estimate individual ancestry and ancestral allele frequencies, we computed 400,000 genome-wide locus-specific branch length (LSBL) Fst statistics of Brazilian Amerindian ancestry compared to European and African; and a similar set of differentiation statistics for their Amerindian component compared with the closest Asian 1000 Genomes population (surprisingly, Bengalis in Bangladesh). After ranking SNPs by these statistics, we ident

SUBMITTER: Mychaleckyj JC 

PROVIDER: S-EPMC5430616 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature