Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure.

ABSTRACT: Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL. The transcription factor Foxo3 integrates the cellular response to oxidative stress and plays a role in extending lifespan in many organisms, including humans. Here we show that Foxo3 is required for auditory function after noise exposure in a mouse model system, measured by ABR. Absent Foxo3, outer hair cells are lost throughout the middle and higher frequencies. SEM reveals persistent damage to some surviving outer hair cell stereocilia. However, DPOAE analysis reveals that some function is preserved in low frequency outer hair cells, despite concomitant profound hearing loss. Inner

SUBMITTER: Gilels F 

PROVIDER: S-EPMC5430619 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature