Refractive index tomograms and dynamic membrane fluctuations of red blood cells from patients with diabetes mellitus.

ABSTRACT: In this paper, we present the optical characterisations of diabetic red blood cells (RBCs) in a non-invasive manner employing three-dimensional (3-D) quantitative phase imaging. By measuring 3-D refractive index tomograms and 2-D time-series phase images, the morphological (volume, surface area and sphericity), biochemical (haemoglobin concentration and content) and mechanical (membrane fluctuation) parameters were quantitatively retrieved at the individual cell level. With simultaneous measurements of individual cell properties, systematic correlative analyses on retrieved RBC parameters were also performed. Our measurements show there exist no statistically significant alterations in morphological and biochemical parameters of diabetic RBCs, compared to those of healthy (non-diabetic) RB

SUBMITTER: Lee S 

PROVIDER: S-EPMC5430658 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature