Ontology highlight
ABSTRACT:
SUBMITTER: Iaconis D
PROVIDER: S-EPMC5430665 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20170427 1
Protein synthesis is traditionally associated with specific cytoplasmic compartments. We now show that OFD1, a centrosomal/basal body protein, interacts with components of the Preinitiation complex of translation (PIC) and of the eukaryotic Initiation Factor (eIF)4F complex and modulates the translation of specific mRNA targets in the kidney. We demonstrate that OFD1 cooperates with the mRNA binding protein Bicc1 to functionally control the protein synthesis machinery at the centrosome where als ...[more]