Ontology highlight
ABSTRACT:
SUBMITTER: Sciortino M
PROVIDER: S-EPMC5430666 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20170425 1
ErbB2 overexpression is detected in approximately 20% of breast cancers and is correlated with poor survival. It was previously shown that the adaptor protein p130Cas/BCAR1 is a crucial mediator of ErbB2 transformation and that its overexpression confers invasive properties to ErbB2-positive human mammary epithelial cells. We herein prove, for the first time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas/ErbB2-mediated invasiveness. Indeed, high Blimp1 expression level ...[more]