Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases.

ABSTRACT: Computationally it was shown that desynchronizing delayed feedback stimulation methods are effective closed-loop techniques for the control of synchronization in ensembles of interacting oscillators. We here computationally design stimulation signals for electrical stimulation of neuronal tissue that preserve the desynchronizing delayed feedback characteristics and comply with mandatory charge deposit-related safety requirements. For this, the amplitude of the high-frequency (HF) train of biphasic charge-balanced pulses used by the standard HF deep brain stimulation (DBS) is modulated by the smooth feedback signals. In this way we combine the desynchronizing delayed feedback approach with the HF DBS technique. We show that such a pulsatile delayed feedback stimulation can effectively and r

SUBMITTER: Popovych OV 

PROVIDER: S-EPMC5430852 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature