Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes.

ABSTRACT: Cells release lipid-bound extracellular vesicles (EVs; exosomes, microvesicles and apoptotic bodies) containing proteins, lipids and RNAs into the circulation. Vesicles mediate intercellular communication between both neighboring and distant cells. There is substantial interest in using EVs as biomarkers for age-related diseases including cancer, and neurodegenerative, metabolic and cardiovascular diseases. The majority of research focuses on identifying differences in EVs when comparing disease states and matched controls. Here, we analyzed circulating plasma EVs in a cross-sectional and longitudinal study in order to address age-related changes in community-dwelling individuals. We found that EV concentration decreases with advancing age. Furthermore, EVs from older individuals were more

SUBMITTER: Eitan E 

PROVIDER: S-EPMC5430958 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature