Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure.

ABSTRACT: Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. The resolution of WFSIM is determined by the period of the optical interference pattern. However, in traditional WFSIM this period is diffraction limited so that pattern having periodicity smaller than 100 nm cannot be generated and as a result achieving an imaging resolution better than 50 nm is a great challenge. Here, we demonstrate a wide-field optical nanoimaging method based on a meta-sandwich structure (MSS) model. It is found that this structure can support standing wave surface plasmons interfere

SUBMITTER: Cao S 

PROVIDER: S-EPMC5431004 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature