Vascular endothelial growth factor-D modulates oxidant-antioxidant balance of human vascular endothelial cells.

ABSTRACT: Vascular endothelial growth factor-D (VEGF-D) is an angiogenic and lymphangiogenic glycoprotein that facilitates tumour growth and distant organ metastasis. Our previous studies showed that VEGF-D stimulates the expression of proteins involved in cell-matrix interactions and promoting the migration of endothelial cells. In this study, we focused on the redox homoeostasis of endothelial cells, which is significantly altered in the process of tumour angiogenesis. Our analysis revealed up-regulated expression of proteins that form the antioxidant barrier of the cell in VEGF-D-treated human umbilical endothelial cells and increased production of reactive oxygen and nitrogen species in addition to a transient elevation in the total thiol group content. Despite a lack of changes in the total ant

SUBMITTER: Papiewska-Pajak I 

PROVIDER: S-EPMC5431135 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature