Ontology highlight
ABSTRACT:
SUBMITTER: Iqbal A
PROVIDER: S-EPMC5431157 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Iqbal Asif A Goldfeder Mauricio Barbugiani MB Marques-Porto Rafael R Asif Huma H Souza Jean Gabriel de JG Faria Fernanda F Chudzinski-Tavassi Ana Marisa AM
Scientific reports 20170503 1
Thrombin is a multifunctional enzyme with a key role in the coagulation cascade. Its functional modulation can culminate into normal blood coagulation or thrombosis. Thus, the identification of novel potent inhibitors of thrombin are of immense importance. Sculptin is the first specific thrombin inhibitor identified in the transcriptomics analysis of tick's salivary glands. It consists of 168 residues having four similar repeats and evolutionary diverged from hirudin. Sculptin is a competitive, ...[more]